MCM蛋白在宫颈上皮内病变中的研究进展

温 俊秀, 张 可心, 王 琦, 宋旭 东*
华北理工大学附属医院

摘要

摘要：微小染色体维持蛋白(MCM蛋白)在真核生物中的功能主要与DNA复制有关，可调节DNA复制，在DNA开始复制和延伸中发挥重要作用，通过多种作用机制控制DNA复制只发生一次。当某些因素引起MCM蛋白发生异常时，处于静止期的细胞重新进入细胞周期，DNA异常复制，最终导致肿瘤的发生，所以MCM蛋白被认为是一种新的肿瘤标志物。MCM与宫颈上皮内病变的发生、发展密切相关，并与宫颈上皮内病变的靶向治疗有关，从而为宫颈上皮内病变的治疗带来新的方向。

关键词

关键词：微小染色体维持蛋白；宫颈上皮内病变

参考

[1]Neves H , Kwok H F .In sickness and in health： The many roles of the minichromosome maintenance proteins[J].Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2017：295.DOI：10.1016/j.bbcan.2017.06.001.[2]Domenico,Maiorano,and,et al.MCM proteins and DNA replication[J].Current Opinion in Cell Biology, 2006.DOI：10.1016/j.ceb.2006.02.006.[3]王东星,周军年,岳文等.微小染色体维持蛋白与肿瘤[J].生物化学与生物物理进展,2018,45(08)：789-797.[4]张梦婷,高盼,杨永秀.微小染色体维持蛋白在卵巢癌中的研究进展[J].医学综述,2014,20(23)：4277-4279.[5]Forsburg S L. Eukaryotic MCM proteins： beyond replication initiation[J]. Microbiology and Molecular Biology Reviews, 2004, 68(1)： 109-131.[6]Bochman M L, Schwacha A. The Mcm2-7 complex has in vitro helicase activity[J]. Molecular cell, 2008, 31(2)： 287-293.[7]Douglas M E, Diffley J F X. Recruitment of Mcm10 to sites of replication initiation requires direct binding to the minichromosome maintenance (MCM) complex[J]. Journal of Biological Chemistry, 2016, 291(11)： 5879-5888.[8]Hosoi A, Sakairi T, Ishimi Y. Binding of MCM-interacting proteins to ATP-binding site in MCM6[J]. Research and Reports in Biology, 2016： 31-40.[9]Brosh R. M., Trakselis M. A. (2019).Fine-tuning of the Replisome： Mcm10 Regulates Fork Progression and Regression.Cell Cycle18(10), 1047–1055[10]Kearsey S E, Labib K. MCM proteins： evolution, properties, and role in DNA replication[J]. Biochimica et Biophysica Acta (BBA)-Gene Structure and Expression, 1998, 1398(2)： 113-136.[11]Liu Y., Richards T. A., Aves S. J. (2009).Ancient Diversification of Eukaryotic MCM DNA Replication Proteins.Bmc Evol. Biol.9, 60. 10.1186/1471-2148-9-60[12]Nishimura K., Ishiai M., Horikawa K., Fukagawa T., Takata M., Takisawa H., et al. (2012).Mcm8 and Mcm9 Form a Complex that Functions in Homologous Recombination Repair Induced by DNA Interstrand Crosslinks.Mol. Cell47(4), 511–522. 10.1016/j.molcel.2012.05.047[13]Cao W, Chen H D, Yu Y W, et al. Changing profiles of cancer burden worldwide and in China： a secondary analysis of the global cancer statistics 2020[J]. Chinese medical journal, 2021, 134(07)： 783-791.[14]Sung H, Ferlay J, Siegel R L, et al. Global cancer statistics 2020： GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA： a cancer journal for clinicians, 2021,71(3)： 209-249.[15]Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018： GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA： a cancer journal for clinicians, 2018, 68(6)： 394-424.[16]Prabhu M, Eckert L O. Development of World Health Organization (WHO) recommendations for appropriate clinical trial endpoints for next-generation Human Papillomavirus (HPV) vaccines[J]. Papillomavirus Research, 2016, 2： 185-189.[17]蒋莉萍,吴凤珍,肖艳等.p16、微型染色体维持蛋白 2、Ki-67在宫颈鳞状上皮内病变的表达与意义[J].现代医学与健康研究电子杂志,2021,5(17)：35-38.[18]陈泉材,韩赛,刘露等.CDC7、MCM4 在 105 例宫颈病变组织中的表达及意义[J].山东大学学报(医学版),2022,60(01)：34-39.