首页出版说明中文期刊中文图书环宇英文官网付款页面

常用血液标志物预测术后谵妄的研究进展

刘娜 娜(, 林哲 昕(, 冯彤 彤(, 高晓 增(

摘要


摘要:术后谵妄(post operative delirium,POD)严重影响外科手术患者术后的转归,有些案例报道甚至影响近期远期预后。目前POD发生的病理生理过程尚不明确,研究POD的相关因子有助于揭示POD的发病机制,有助于早期识别高危患者,预防各类不良事件的发生。一些研究表明,有些血液标志物手术前后的变化率可作为预测并识别POD的指标。文章从炎症介质相关标志物、神经损伤相关标志物两个临床常用指标类别回顾老年患者常用POD血液标志物手术前后变化情况的研究,为临床术后及时干预POD症状提供证据。

关键词


关键词:血液标志物;术后谵妄;预测

全文:

PDF


参考


[1]中国老年医学学会麻醉学分会,中国老年患者术后谵妄防治专家共识.国际麻醉学与复苏杂志,2023,44(01) : 1-27. DOI: 10.3760/cma.j.cn321761-20220915-10005[2]Osse RJ, Fekkes D, Tulen JH, et al. High preoperative plasmaneopterin predicts delirium after cardiac surgery in older adults[J].J Am Geriatr Soc,2012,60(4):661⁃668.DOI:10.1111/j.1532⁃5415.2011.03885.x.[3]Furtado S V, Basu E, Mehta A, et al. Surgical outcome ofencephaloduroarteriomyosynangiosis for moyamoya disease[J]. Neurology India, 2021, 69(5): 1259.[4]彭文勇,吕华燕,廖俊锋等.允许性高碳酸血症对沙滩椅体位肩关节镜手术患者脑氧饱和度和术后认知功能的影响[J].中国内镜杂志,2020,26(05):37-42.[5]树栋,王坤,刘海鹰等.乌司他丁对老年重度烧伤患者切痂术后认知功能障碍和血清 S100β蛋白及 NSE 的影响[J].中国老年学杂志,2022,42(19):4701-4705.[6]Bayram H,Hidiroglu M,Cetin L,Kucuker A,Iriz E,Uguz E,Saglam F,Sener E.ComparingS-100 beta protein levels and neurocognitive functions between patients undergoing on-pumpand off-pump coronary artery bypass grafting[J].J Surg Res,2013,182(2):198-202.[7]Züngün C,Yilmaz FM,Tutkun E,Yilmaz H,Uysal S.Assessme-nt of serum S100B andneuron specific enolase levels to evaluate the neurotoxıc effects of organıc solvent exposure[J].Clin Toxicol(Phila),2013,51(8):748-751.[8]Chi YL,Li ZS,Lin CS,Wang Q,Zhou YK.Evaluation of the postoperative cognitivedysfunction in elderly patients with general anesthesia[J].Eur Rev Med Pharmacol Sci,2017,21(6):1346-1354.[9]钱晓波,季东凯,倪海波.重型颅脑损伤患者血清 NSE 及CRP 检测及其意义[J].系统医学,2022,7(13):19-22.DOI:10.19368/j.cnki.2096-1782.2022.13.019.[10]Anderson BJ,Chesley CF,Theodore M,et al. Incidence,riskfactors,and clinical implications of post-operative delirium inlung transplant recipients.J Heart Lung Transplant,2018,37( 6) : 755-762.[11]Fong TG, Vasunilashorn SM, Ngo L, et al. Association of plasmaneurofilament light with postoperative delirium[J]. Ann Neurol,2020, 88(5): 984⁃994. DOI:10.1002/ana.25889.[12]黄中龙,杨志勇.神经丝蛋白轻链多肽在脑损伤评估中的应用进展[J].医学综述,2022,28(13):2635-2639.[13]Guo T,Noble W,Hanger DP. Roles of tau protein in health anddisease. Acta Neuropathol,2017,133( 5) : 665-704.[14]Fan Q,He W,Gayen M,et al. Activated CX3CL1 / Smad2signals prevent neuronal loss and Alzheimer's Tau pathology-me-diated cognitive dysfunction. J Neurosci, 2020, 40 ( 5 ) :1133-1144.[15]Ballweg T, White M, Parker M, et al. Association between plas⁃ma tau and postoperative delirium incidence and severity: apro⁃spective observational study[J]. Br J Anaesth, 2021, 126(2): 458⁃466. DOI:10.1016/j.bja.2020.08.061.[16]Shin MK,Vázquez-Rosa E,Koh Y,et al. Reducing acetylatedtau is neuroprotective in brain injury. Cell,2021,184 ( 10 ) :2715-2732.[17]Yamanashi T,Malicoat JR,Steffen KT,et al. Bispectral EEG(BSEEG) quantifying neuro-inflammation in mice induced bysystemic inflammation:a potential mouse model ofdelirium[J]. J Psychiatr Res,2021,133: 205-211.[18]Knaak C, Vorderwülbecke G, Spies C, et al. C⁃reactive protein forrisk prediction of post⁃operative delirium and post⁃operative neu⁃rocognitive disorder[J]. Acta Anaesthesiol Scand, 2019, 63(10):1282⁃1289. DOI:10.1111/aas.13441.[19]张薇,刘会,张亚岚,等. 脑小血管病致认知障碍的危险因素研究进展[J]. 解放军医学院学报,2021,42(2): 235-238.[20]Noah AM,Almghairbi D,Evley R,et al. Preoperativeinflammatory mediators and postoperative delirium:systematicreview and meta-analysis[J]. Br J Anaesth,2021,127(3):424-434.[21]Adamis D,van Gool WA,Eikelenboom P. Consistent patterns inthe inconsistent associations of Insulin-like growth factor 1 (IGF-1),C-Reactive Protein (C-RP) and Interleukin 6 (IL-6) levelswith delirium in surgical populations. A systematic review andmeta-analysis[J]. Arch Gerontol Geriatr,2021,97: 104518.[22]Zhang WC,Wang TL,Wang G,et al. Effects ofdexmedetomidine on postoperative delirium and expression of IL-1β,IL-6,and TNF-α in elderly patients after hip fractureoperation[J]. Front Pharmacol,2020,11: 678.




DOI: http://dx.doi.org/10.12361/2661-3603-06-01-155994

Refbacks

  • 当前没有refback。