糖化血红蛋白变异指数与糖尿病慢性病发症的关系

崔金 月1, 王颖 2（, 李鑫 1（

摘要

摘要：糖化血红蛋白（Glycosylated haemoglobin，HbA1c），被当做是评估糖尿病患者血糖控制和治疗结果的“金标准”，但存在个体差异，影响血糖的准确解释。糖化血红蛋白变异指数（hemoglobin glycation index，HGI）是衡量 HbA1c 个体变异性的指标可用于糖尿病患者的管理和治疗。本综述对 HGI 与糖尿病慢性并发症的关系进行探讨。

关键词

关键词：糖化血红蛋白变异指数；糖尿病慢性并发症

参考

[1]Hempe,J.M.,etal.,Highandlowhemoglobinglycationphenotypesintype1diabetes:achallengeforinterpretationofglycemiccontrol.JDiabetesComplications,2002.16(5):p.313-320.[2]Joung,H.N.,etal.,ConsistencyoftheGlycationGapwiththeHemoglobinGlycationIndexDerivedfromaContinuousGlucoseMonitoringSystem.EndocrinolMetab(Seoul),2020.35(2):p.377-383.[3]Klein,K.R.,etal.,Hemoglobinglycationindex,calculatedfromasinglefastingglucosevalue,asapredictiontoolforseverehypoglycemiaandmajoradversecardiovasculareventsinDEVOTE.BMJOpenDiabetesResCare,2021.9(2).[4]Xu,S.,etal.,Thehemoglobinglycationindexpredictstheriskofadversecardiovasculareventsincoronaryheartdiseasepatientswithtype2diabetesmellitus.FrontCardiovascMed,2022.9:p.992252.[5]Wu,J.D.,etal.,AssociationBetweenHemoglobinGlycationIndexandRiskofCardiovascularDiseaseandAllCauseMortalityinType2DiabeticPatients:AMeta-Analysis.FrontCardiovascMed,2021.8:p.690689.[6]黄崇兵,王思宏,倪孝兵,糖化血红蛋白变异指数与2型糖尿病微血管病变的关系.中国处方药,2021.19(10):p.170-171.[7]Xin,S.,etal.,Associationbetweenhemoglobinglycationindexanddiabetickidneydiseaseintype2diabetesmellitusinChina:Across-sectionalinpatientstudy.FrontEndocrinol(Lausanne),2023.14:p.1108061.[8]汤春梦,等.,血红蛋白糖化指数与2型糖尿病患者视网膜病变的相关性研究.中国糖尿病杂志,2021.29(05):p.349-352.[9]陈晓正,等.,糖化血红蛋白变异指数与糖尿病视网膜病变的相关性研究.中国糖尿病杂志,2018.26(03):p.188-192.[10]McCarter,R.J.,etal.,BiologicalvariationinHbA1cpredictsriskofretinopathyandnephropathyintype1diabetes.DiabetesCare,2004.27(6):p.1259-1264.[11]Fiorentino,T.V.,etal.,Elevatedhemoglobinglycationindexidentifynon-diabeticindividualsatincreasedriskofkidneydysfunction.Oncotarget,2017.8(45):p.79576-79586.[12]于晓濛,贺维峰,王宁,糖化血红蛋白变异指数与糖尿病周围神经病变的相关性分析.中华实用诊断与治疗杂志,2019.33(12):p.1194-1197.[13]盛忠奇and张真稳,糖化血红蛋白指数与2型糖尿病周围神经病变的相关性研究.中国现代医学杂志,2019.29(24):p.78-81.