不同麻醉深度在结直肠癌患者腹腔镜根治术中的应用分析

凯赛 尔·, 阿布 都沙
新疆医科大学附属肿瘤医院

摘要

摘要：目的:探析不同麻醉深度在结直肠癌患者腹腔镜根治术中的应用价值。方法:选取2020年1月~2021年1月在医院接受腹腔镜根治术的100例结直肠癌患者作为研究对象，采用随机数字表法分为2组各50例。A组患者在术中脑电双频指数(BIS)维持在50~59，B组患者术中脑电双频指数BIS维持在40~49。统计2组临床指标[手术时间、首次肛门排气时间、肠鸣音恢复时间、肛门首次排便时间、进食恢复时间]，麻醉诱导前、插管时、切皮时、术毕时记录2组血流动力学指标[心率(HR)、均动脉压(MAP)、血氧饱和度(SpO2)]，比较2组术前、术后12h、术后24h及术后72h时的炎症因子指标[白细胞介素(IL)-6、IL-17、IL-10]。结果:B组首次肛门排气时间、肠鸣音恢复时间、肛门首次排便时间均短于A组，差异有统计学意义(P＜0.05)；2组手术时间、进食恢复时间比较差异无统计学意义(P＞0.05)；术后麻醉诱导前、插管时、切皮时、术毕时，2组间的HR、MAP比较，差异有统计学意义(P＜0.05)，B组HR、MAP高于A组(P＜0.05)；A组与B组麻醉诱导前的HR、MAP与插管时、切皮时、术毕时比较差异有统计学意义(P＜0.05)。2组不同时点的SpO2比较差异无统计学意义(P＞0.05)；术前、术后12h、术后24h、术后72h时，2组间的血清IL-6、IL-17、IL-10水平比较，差异有统计学意义(P＜0.05)，B组血清IL-6、IL-17水平低于A组，血清IL-10水平高于A组(P＜0.05)；A组与B组术前的血清IL-6、IL-17、IL-10水平与术后12h、术后24h、术后72h时比较差异有统计学意义(P＜0.05)。结论:全身麻醉时BIS维持在40~49可减轻结直肠癌患者腹腔镜根治术引起的炎症反应，利于维持术中血流动力学稳定，促进肠道功能恢复。

关键词

关键词：结直肠癌；腹腔镜结直肠癌根治术；麻醉深度；炎症因子；血流动力学

参考

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