中国汉族人群HLAⅠ类等位基因与宫颈癌发生的相关性研究

朱雷 雷1, 肖田 田2, 胡海 燕3, 郑 峥3, 李卫 红3, 赵卫 华4

摘要

摘要：目的：探讨中国汉族人群HLAⅠ类等位基因(HLA-A、-B、-C)与宫颈癌发生的相关性。方法：随机采集265例宫颈上皮内瘤样病变和宫颈癌患者及200名健康妇女的外周血样本，应用HLAPCR-rSSO方法对各样本进行HLA-A、-B、-C基因分型，对比分析各病例组(CIN1组、CIN2/3组、宫颈癌组)与对照组间HLAⅠ类等位基因检出频率的差异。结果：在低分辨水平，HLA-A*02、HLA-B*46在CIN2/3组中的基因频率显著高于健康对照组(P=0.032和P=0.004)，HLA-C*15在宫颈癌组中的基因频率显著高于健康对照组(P=0.04)；在高分辨水平，HLA-B*46:01在CIN2/3组中的基因频率显著高于健康对照组(P=0.004)，HLA-C*12:02在宫颈癌组中的基因频率显著高于健康对照组(P=0.034)。结论：汉族人群HLA-A*02、HLA-B*46:01、HLA-C*12:02和HLA-C*15为宫颈癌发生的易感性等位基因，可能对促进宫颈癌发生发展具有免疫学方面的影响。

关键词

关键词：宫颈癌；人类白细胞抗原(HLA)；等位基因；汉族

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