RNA结合蛋白HuR研究及其在胃癌发生发展中的作用

张一 宁1, 薛明 团2
1.赤峰学院临床医学院 内蒙古赤峰 024000 2.赤峰学院附属医院 内蒙古赤峰 024000

摘要

摘要：RNA结合蛋白(RNA-binding proteins，RBP)是基因转录后的重要调节因子，靶mRNA稳定性及靶蛋白的翻译过程参与机体生命活动。在所有RBP中，HuR是特征性最好、唯一在人体各个组织中普遍表达的RNA结合蛋白，RNA结合蛋白HuR是胚胎致死性异常视觉基因(ELAVL1)的蛋白质产物，它几乎在所有癌症中均过表达。近年来，多项研究发现HuR通过转录、转录后调控及翻译后修饰来稳定靶mRNA及调节靶基因的翻译参与机体生命过程。本文重点讨论HuR功能及其在胃癌发生发展中的作用以期为胃癌治疗提供新的靶点。

关键词

关键词：RNA结合蛋白；HuR蛋白；胃癌

参考

[1]PABIS M, POPOWICZ G M, STEHLE R, et al. HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs [J]. Nucleic acids research, 2019, 47(2): 1011-1029.[2]ZHANG R, WANG J. HuR stabilizes TFAM mRNA in an ATM/p38-dependent manner in ionizing irradiated cancer cells [J]. Cancer science, 2018, 109(8): 2446-2457.[3]JEYARAJ S C, SINGH M, AYUPOVA D A, et al. Transcriptional control of human antigen R by bone morphogenetic protein [J]. The Journal of biological chemistry, 2010, 285(7): 4432-4440.[4]JIN H, CHEN Y, REN J, et al. TERC suppresses PD-L1 expression by downregulating RNA binding protein HuR [J]. Science China Life sciences, 2022, 65(12): 2505-2516.[5]MENG Z, KING P H, NABORS L B, et al. The ELAV RNA-stability factor HuR binds the 5'-untranslated region of the human IGF-IR transcript and differentially represses cap-dependent and IRES-mediated translation [J]. Nucleic acids research, 2005, 33(9): 2962-2979.[6]REGLERO C, LAFARGA V, RIVAS V, et al. GRK2-Dependent HuR Phosphorylation Regulates HIF1αActivation under Hypoxia or Adrenergic Stress [J]. Cancers, 2020, 12(5):1216.[7]DAKS A, PETUKHOV A, FEDOROVA O, et al. The RNA-binding protein HuR is a novel target of Pirh2 E3 ubiquitin ligase [J]. Cell death & disease, 2021, 12(6): 581.[8]GUO T, DAI Z, YOU K, et al. S-adenosylmethionine upregulates the angiotensin receptor-binding protein ATRAP via the methylation of HuR in NAFLD [J]. Cell death & disease, 2021, 12(4): 306.[9]WANG W, SUN Z, DENG J, et al. [Integration and analysis of associated data in surgical treatment of gastric cancer based on multicenter, high volume databases] [J]. Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery, 2016, 19(2): 179-185.[10]YANG F, HU A, LI D, et al. Circ-HuR suppresses HuR expression and gastric cancer progression by inhibiting CNBP transactivation [J]. Molecular cancer, 2019, 18(1): 158.[11]WU W, XU S, GUAN K, et al. 5-FU blocks shuttling of HuR mediated by PKCδ in gastric cancer cells [J]. Translational cancer research, 2020, 9(8): 4790-4799.[12]LIU N, JIANG F, YE M, et al. HuR confers IL-17a-induced migration and invasion of gastric cancer cells via upregulation of Snail translation [J]. Cytokine, 2022, 153：155830.