炎症微环境与肿瘤关系的研究进展

张 昭1¹, 阿合 提别²
1、1.新疆医科大学第二临床医学院 乌鲁木齐 830000；2.新疆医科大学第二附属医院普外科 乌鲁木齐 830000
2、通讯作者 1.新疆医科大学第二临床医学院 乌鲁木齐 830000；2.新疆医科大学第二附属医院普外科 乌鲁木齐 830000

摘要

摘要：近年来，我们对癌症的认识发生了根本性的变化。从过去认为癌症是一个基因突变性疾病，到现在认为是一个复杂的生态系统，其中涉及到广泛的非癌细胞及其内部相互作用。我们意识到基因改变是必然的，但对于癌症的发生和发展是有限的。在显微镜下观察到的肿瘤微环境(TumorMicroenvironment，TME)是一个高度结构化的生态系统，包含癌症细胞被多种非癌细胞类型包围、共同嵌入、血管化的整体。TME包括丰富多样的免疫细胞、癌症相关成纤维细胞(CAFs)、内皮细胞(EC)和其他因组织而异的细胞类型，TME细胞及其分泌分子在癌症的发病机制中起关键作用，在以后的研究中，可能通过改变肿瘤微环境，限制肿瘤的发展和转移，成为新的治疗靶点。

关键词

关键词：肿瘤微环境；研究进展

参考

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