抑郁障碍的快感缺失与认知功能损害的相关研究进展

范少 航1, 张云 淑2, 李冰 2,, 栗克 清2
1.华北理工大学研究生院 河北唐山 063210 2.河北省精神卫生中心 3.河北省重大精神与行为障碍疾病研究重点实验室 4.河北大学第六临床医学院

摘要

摘要：抑郁障碍是一种常见的精神疾病，持续情绪低落、兴趣减退是其典型临床症状。抑郁障碍的异质性使得我们应该对抑郁障碍进行分型研究，伴忧郁特征的抑郁障碍被发现在认知功能损害方面比不伴忧郁特征的抑郁障碍更差，抑郁障碍的典型症状之一“快感缺失”经重新描述划分后具有更多的研究潜力，抑郁障碍的快感缺失被发现与疾病的严重程度、自杀意念、抗抑郁治疗效果等存在相关性，同时被发现与多项认知功能损害之间存在相关关系，但在前人的研究中存在一些冲突的结果，经对比发现，可能与他们研究中对快感缺失的定义存在分歧，并使用的研究工具具体研究的功能对象不一致有关，为了澄清这些疑点，在未来对研究的更进一步细化是有必要的。

关键词

关键词：抑郁障碍；认知功能损害；伴忧郁特征抑郁障碍；快感缺失

参考

[1]ZHU J, WANG Z, GONG T, et al. An Improved Classification Model for Depression Detection Using EEG and Eye Tracking Data[J]. IEEE Transactions on NanoBioscience, 2020, 19(3): 527-537. DOI:10.1109/tnb.2020.2990690.[2]NGUYEN C, MURRAY G, ANDERSON S, et al. In Vivo Molecular Chronotyping, Circadian Misalignment, and High Rates of Depression in Young Adults[J]. Journal of Affective Disorders, 2019, 250:425-431. DOI:10.1016/j. jad.2019.03.050.[3]郝萌萱, 尹孟凡, 夏笑清, 等. 1990年与 2019年中国人群抑郁症疾病负担分析[J]. 中国慢性病预防与控制, 2022.[4]GONG L, HE C, ZHANG H, et al. Disrupted Reward and Cognitive Control Networks Contribute to Anhedonia in Depression[J]. Journal of Psychiatric Research, 2018, 103: 61-68. DOI:10.1016/j.jpsychires.2018.05.010.[5]ROCA M, AMO A R-L del, RIERA-SERRA P, et al. Suicidal Risk and Executive Functions in Major Depressive Disorder: A Study Protocol[J]. BMC Psychiatry, 2019, 19(1). DOI:10.1186/s12888-019-2233-1.[6]TSYPES A, OWENS M, GIBB B E. Suicidal Ideation and Attentional Biases in Children: An Eye-Tracking Study[J]. Journal of Affective Disorders, 2017, 222: 133-137. DOI:10.1016/j.jad.2017.07.012.[7]LAZAROV A, BEN-ZION Z, SHAMAI D, et al. Free Viewing of Sad and Happy Faces in Depression: A Potential Target for Attention Bias Modification[J]. Journal of Affective Disorders, 2018, 238: 94-100. DOI:10.1016/j.jad. 2018.05.047.[8]DEHN L B, BEBLO T. Depressed, biased, forgetful: The interaction of emotional and cognitive dysfunctions in depression[J].neuropsychiatrie,2019,33(3):123-130. DOI:10.1007/s40211-019-0307-4.[9]PHILLIPS W J, HINE D W, THORSTEINSSON E B. Implicit Cognition and Depression: A Meta-Analysis[J]. Clinical Psychology Review,2010,30(6):691-709.DOI:10.1016/j.cpr.2010.05.002.[10]DOTSON V M,MCCLINTOCK S M,VERHAEGHEN P, et al. Depression and Cognitive Control across the Lifespan: A Systematic Review and Meta-Analysis[J]. Neuropsychology Review,2020,30(4):461-476. DOI:10.1007/s11065-020-09436-6.[11]宋妍, 张玲, 何梅, 等. 认知功能与抑郁症状的关系研究[J]. 华夏医学, 2023.[12]符浩. 三种不同亚型抑郁障碍患者睡眠特征的对照研究[D]//上海交通大学. .[13]JURUENA M F, CALIL H M, FLECK M P, et al. Estudos latino-americanos sobre melancolia: um transtorno do humor melhor definido para o CID-11[J]. Revista Brasileira de Psiquiatria, 2011, 33(suppl 1): s37-s47. DOI:10.1590/s1516-44462011000500005.[14]QUINN C, HARRIS A, KEMP A. The Interdependence of Subtype and Severity: Contributions of Clinical and Neuropsychological Features to Melancholia and Non-Melancholia in an Outpatient Sample[J]. Journal of the International Neuropsychological Society, 2012, 18(2): 361-369. DOI:10.1017/s1355617711001858.[15]梁思想. 抑郁症功能特点和静息态脑功能影像关联研究[D]//天津医科大学. .[16]MOHN C, RUND B R. Neurognitive Function and Symptom Remission 2 Years after ECT in Major Depressive Disorders[J]. Journal of Affective Disorders, 2019, 246: 368-375. DOI:10.1016/j.jad.2018.12.083.[17]高翔. 无痉挛电休克治疗对抑郁症患者记忆功能的影响分析[J]. 大家健康(学术版), 2014.[18]GY R R, JV R-L, J R G, et al. Effect of Transcranial Magnetic Stimulation as an Enhancer of Cognitive Stimulation Sessions on Mild Cognitive Impairment: Preliminary Results[J]. Psychiatry Research, 2021, 304: 114151. DOI:10.1016/j.psychres.2021.114151.[19]ZHANG W, ZHU N, LAI J, et al. Reliability and Validity of THINC-It in Evaluating Cognitive Function of Patients with Bipolar Depression[J]. Neuropsychiatric Disease and Treatment, 2020, Volume 16: 2419-2428. DOI: 10.2147/ndt.s266642.[20]刘虹宏. 抑郁症认知功能损害研究进展[D]//重庆医科大学. .[21]杨丽颖, 郑月, 康传依, 等. 眼动追踪技术应用于抑郁障碍患者注意偏向观察的研究进展[J]. 神经疾病与精神卫生, 2021.[22]HOPPER L M, GULLI R A, HOWARD L H, et al. The Application of Noninvasive, Restraint-Free Eye-Tracking Methods for Use with Nonhuman Primates[J]. Behavior Research Methods,2020,53(3):1003-1030. DOI:10.3758/s13428-020-01465-6.[23]NEMETH V L, CSETE G, DROTOS G, et al. The Effect of Emotion and Reward Contingencies on Relational Memory in Major Depression: An Eye-Movement Study with Follow-Up[J]. Frontiers in Psychology, 2016, 7. DOI:10. 3389/fpsyg.2016.01849.[24]BUJANOW A,BODENSCHATZ C M, SZYMANSKAM, et al. The Relationship between Dispositional Attention to Feelings and Visual Attention to Emotion[J]. Progress inNeuro-Psychopharmacology and Biological Psychiatry,2020,100:109882. DOI:10.1016/j.pnpbp.2020.109882.[25]PLATT B, SFÄRLEA A, BUHL C, et al. An Eye-Tracking Study of Attention Biases in Children at High Familial Risk for Depression and Their Parents with Depression[J]. Child Psychiatry & Human Development, 2021, 53(1): 89-108. DOI:10.1007/s10578-020-01105-2.[26]贾海玲, 王丽, 安静, 等. 快感缺失量表中文版在中国抑郁症患者中的信效度研究[J]. 中华精神科杂志, 2020, 53(3): 216-220.[27]HALLFORD D J, RUSANOV D, YEOW J J E, et al. Overgeneral and Specific Autobiographical Memory Predict the Course of Depression: An Updated Meta-Analysis[J]. Psychological Medicine, 2021, 51(6): 909-926. DOI:10.1017/s0033291721001343.[28]FANG J, DONG Y. Autobiographical Memory Disturbance in Depression[J]. Psychology, Health & Medicine, 2021,27(7):1618-1626.DOI:10.1080/13548506.2021.1916954.[29]ZHOU F-C, WANG Y-Y, ZHENG W, et al. Prospective Memory Deficits in Patients with Depression: A Meta-Analysis[J]. Journal of Affective Disorders, 2017, 220: 79-85. DOI:10.1016/j.jad.2017.05.042.[30]BARCH D M, HARMS M P, TILLMAN R, et al. Early Childhood Depression, Emotion Regulation, Episodic Memory, and Hippocampal Development.[J]. Journal of Abnormal Psychology, 2019, 128(1): 81-95. DOI:10.1037/abn0000392.[31]NIKOLIN S, TAN Y Y, SCHWAAB A, et al. An Investigation of Working Memory Deficits in Depression Using the N-Back Task: A Systematic Review and Meta-Analysis[J]. Journal of Affective Disorders, 2021, 284: 1-8. DOI:10.1016/j.jad.2021.01.084.[32]YAROSLAVSKY I, ALLARD E S, SANCHEZ-LOPEZ A. Can’t Look Away: Attention Control Deficits Predict Rumination, Depression Symptoms and Depressive Affect in Daily Life[J]. Journal of Affective Disorders, 2019, 245: 1061-1069. DOI:10.1016/j.jad.2018.11.036.[33]MARAMIS M M, MAHAJUDIN M S, KHOTIB J. Impaired Cognitive Flexibility and Working Memory Precedes Depression: A Rat Model to Study Depression[J]. Neuropsychobiology, 2020, 80(3): 225-233. DOI:10.1159/000508682.[34]MOREA A, CALVETE E. Cognitive Flexibility and Selective Attention ’ s Associations with Internalizing Symptoms in Adolescents: Are They Reciprocal?[J]. Journal of Youth and Adolescence,2021,50(5):921-934. DOI: 10.1007/s10964-021-01402-6.[35]PAN Z, PARK C, BRIETZKE E, et al. Cognitive Impairment in Major Depressive Disorder[J]. CNS Spectrums, 2018, 24(1): 22-29. DOI:10.1017/s1092852918001207.[36]ROCK P L, ROISER J P, RIEDEL W J, et al. Cognitive Impairment in Depression: A Systematic Review and Meta-Analysis[J]. Psychological Medicine, 2013, 44(10): 2029-2040. DOI:10.1017/s0033291713002535.[37]BOSAIPO N B, FOSS M P, YOUNG A H, et al. Neuropsychological Changes in Melancholic and Atypical Depression: A Systematic Review[J]. Neuroscience & Biobehavioral Reviews, 2017, 73: 309-325. DOI:10. 1016/j.neubiorev.2016.12.014.[38]WINOGRAD-GURVICH C, GEORGIOU-KARISTIANIS N, FITZGERALD P B, et al. Ocular Motor Differences between Melancholic and Non-Melancholic Depression[J]. Journal of Affective Disorders, 2006, 93(13): 193-203. DOI:10.1016/j.jad.2006.03.018.[39]HYETT M, PARKER G, BREAKSPEAR M. Bias and Discriminability during Emotional Signal Detection in Melancholic Depression[J]. BMC Psychiatry, 2014, 14(1). DOI:10.1186/1471-244x-14-122.[40]EXNER C, LANGE C, IRLE E. Impaired Implicit Learning and Reduced Pre-Supplementary Motor Cortex Size in Early-Onset Major Depression with Melancholic Features[J]. Journal of Affective Disorders, 2009, 119(1-3): 156-162. DOI:10.1016/j.jad.2009.03.015.[41]梁健宁, 顾雨婷, 周晨, 等. 抑郁症外显和内隐情绪性反应抑制缺损及其与快感缺失的关系[C]//第二十三届全国心理学学术会议论文集. .[42]WITHALL A, HARRIS L M, CUMMING S R. A Longitudinal Study of Cognitive Function in Melancholic and Non-Melancholic Subtypes of Major Depressive Disorder[J]. Journal of Affective Disorders, 2010, 123(1-3): 150-157. DOI:10.1016/j.jad.2009.07.012.[43]DAY C V, GATT J M, ETKIN A, et al. Cognitive and Emotional Biomarkers of Melancholic Depression: An ISPOT-D Report[J]. Journal of Affective Disorders, 2015, 176: 141-150. DOI:10.1016/j.jad.2015.01.061.[44]LIN K, XU G, LU W, et al. Neuropsychological Performance in Melancholic, Atypical and Undifferentiated Major Depression during Depressed and Remitted States: A Prospective Longitudinal Study[J]. Journal of Affective Disorders, 2014, 168: 184-191. DOI:10.1016/j.jad.2014.06.032.[45]孔淑琪, 吕洞宾, 洪武, 等. 抑郁障碍快感缺失的机制、评估和治疗进展[J]. 临床精神医学杂志, 2022.[46]DUCASSE D, LOAS G, DASSA D, et al. Anhedonia Is Associated with Suicidal Ideation Independently of Depression: A Meta-Analysis[J]. Depression and Anxiety, 2017, 35(5): 382-392. DOI:10.1002/da.22709.[47]谢爱玲.单相和双相抑郁障碍奖赏功能异常的脑功能网络研究[D]//电子科技大学. .[48]KRING A M, BARCH D M. The Motivation and Pleasure Dimension of Negative Symptoms: Neural Substrates and Behavioral Outputs[J]. European Neuropsychop harmacology,2014, 24(5): 725-736. DOI:10.1016/j. euroneuro.2013. 06.007.[49]姜文颢. 抑郁症快感缺失多元数据驱动的遗传影像学研究[D]//东南大学. .[50]陈映梅, 陈敏敏, 蔡颖莲, 等. 首发精神病患者快感缺失水平与认知功能的关系[J]. 四川精神卫生, 2021.[51]杨洁. 认知理论模型下首发抑郁症个体的认知功能与症状关系研究[D]//安徽医科大学. .[52]KRINGS A, HEEREN A, FONTAINE P, et al. Attentional Biases in Depression: Relation to Disorder Severity, Rumination, and Anhedonia[J]. Comprehensive Psychiatry, 2020, 100: 152173. DOI:10.1016/j.compps ych.2020.152173.[53]LIAO A, WALKER R, CARMODY T J, et al. Anxiety and Anhedonia in Depression: Associations with Neuroticism and Cognitive Control[J]. Journal of Affective Disorders, 2019, 245: 1070-1078. DOI:10.1016/j.jad.2018.11.072.[54]龚亮. 抑郁症快感缺失与多巴胺通路基因多态性的脑网络机制研究[D]//东南大学. .[55]THOMPSON P M, JAHANSHAD N, CHING C R K, et al. ENIGMA and Global Neuroscience: A Decade of Large-Scale Studies of the Brain in Health and Disease across More than 40 Countries[J]. Translational Psychiatry, 2020, 10(1). DOI:10.1038/s41398-020-0705-1.[56] SCHMAAL L, HIBAR D P, SÄMANN P G, et al. Cortical Abnormalities in Adults and Adolescents with Major Depression Based on Brain Scans from 20 Cohorts Worldwide in the ENIGMA Major Depressive Disorder Working Group[J]. Molecular Psychiatry, 2016, 22(6): 900-909. DOI:10.1038/mp.2016.60.