二甲双胍对缺氧条件下心肌收缩力影响的相关研究进展

王 译欧, 王 玥, 王 志行, 王 梓霖, 钟 之含, 周 代锋
海南医学院

摘要

二甲双胍是现阶段临床常用的降糖药，对 2 型糖尿病（Type 2 Diabetes Mellitus ,T2DM）起很好的控制效果，但近些年的研究表明二甲双胍的作用效果除降血糖、改善胰岛素抵抗【1】外，还具有抗炎、抗肿瘤【2】、心血管保护【3】、治疗多囊卵巢综合征【4】等多种效应以及具有“抗心力衰竭”【5】以及抑制心肌缺血再灌注损伤（Myocardium Ischemia /Reperfusion，I/R）【6】等作用。我们有理由认为它也对由于体内一系列炎症或氧化应激反应导致的心肌收缩力下降有影响。故本文对二甲双胍作用于心血管疾病与缺氧条件下心肌收缩力下降的机制的相关性进行分析整理，以进一步探究二甲双胍对缺氧条件下心肌收缩力的影响，为深入研究二甲双胍更多功能奠定基础和为临床上治疗由心肌受损引起的心血管疾病提供帮助和药物参考。

关键词

二甲双胍；临床应用；心肌收缩力

参考

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