子宫内膜容受性影响因素的研究进展

郭 慧勤, 齐 敬儒, 刘 美辰, 张 明明
黑龙江中医药大学 黑龙江哈尔滨 150040

摘要

目的：胚胎植入是一个复杂的过程，涉及发育良好的胚胎和子宫内膜容受性之间的协调同步。子宫内膜容受性的调节机制复杂，本文将炎症、糖原代谢、脂代谢和相关分子标志物等方面对子宫内膜容受性的影响因素进行综述，希望能够为子宫内膜容受性建立的具体机制及临床治疗提供新的思路。

关键词

子宫内膜容受性；炎症；糖原代谢；脂代谢；分子标志物

参考

[1]Melford Sarah E,Taylor Anthony H,Konje Justin C,Of mice and (wo)men: factors influencing successful implantation including endocannabinoids.[J] .Hum Reprod Update, 2014, 20: 415-28. [2]Plaks Vicki,Birnberg Tal,Berkutzki Tamara et al. Uterine DCs are crucial for decidua formation during embryo implantation in mice.[J] .J Clin Invest, 2008, 118: 3954-65. [3]Gnainsky Y,Granot I,Aldo P et al. Biopsy-induced inflammatory conditions improve endometrial receptivity: the mechanism of action.[J] .Reproduction, 2015, 149: 75-85. [4]Xu Bufang,Sun Xiaoxi,Li Lu et al. Pinopodes, leukemia inhibitory factor, integrin-β3, and mucin-1 expression in the peri-implantation endometrium of women with unexplained recurrent pregnancy loss.[J] .Fertil Steril, 2012, 98: 389-95. [5]成芳,卿松,蔡霞.整合素β3、白血病抑制因子在输卵管积水患者子 宫 内 膜 组 织 中 表 达 的 变 化 及 意 义 [J]. 中 国 现 代 医 学 杂志,2012,22(25):37-41. [6]Boomsma C M,Kavelaars A,Eijkemans M J C et al. Endometrial secretion analysis identifies a cytokine profile predictive of pregnancy in IVF.[J] .Hum Reprod, 2009, 24: 1427-35. [7]Gibson Charlotte,de Ruijter-Villani Marta,Rietveld Jolanda et al. Expression of glucose transporters in the endometrium and early conceptus membranes of the horse.[J] .Placenta, 2018, 68: 23-32. [8]Lim H,Gupta R A,Ma W G et al. Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdelta.[J] .Genes Dev, 1999, 13: 1561-74. [9]Heng Sophea,Samarajeewa Nirukshi,Aberkane Asma et al. Podocalyxin inhibits human embryo implantation in vitro and luminal podocalyxin in putative receptive endometrium is associated with implantation failure in fertility treatment.[J] .Fertil Steril, 2021, 116: 1391-1401. [10]Heng Sophea,Samarajeewa Nirukshi,Wang Yao et al. Podocalyxin promotes an impermeable epithelium and inhibits pro-implantation factors to negatively regulate endometrial receptivity.[J] .Sci Rep, 2021, 11: 24016.