阻断 MASP-2 蛋白依赖的补体凝集素途径活化的抗体开发

吴 易潘
上海麦济生物技术有限公司 201203

摘要

目的：补体是人体先天免疫系统之一，在对抗感染方面起着重要作用，补体系统的上游激活途径包括三条：经典途径（CP），凝集素途径（LP），旁路/替代途径（AP）。补体的功能失调或者过度激活会导致一些罕见的疾病，如阵发性夜间血红蛋白尿（PNH），非典型溶血性尿毒症综合征（aHUS），造血干细胞移植相关血栓性微血管病（HSCT-TMA）等等，IgA 肾病（IgAN）中也涉及到补体凝集素途径和旁路途径的激活。甘露聚糖结合凝集素丝氨酸蛋白酶 2（MASP-2）是补体凝集素途径的关键催化酶，阻断 MASP-2 的功能可以成功阻断补体凝集素途径，从而减轻由于补体过度激活导致的对人体的损伤。本研究开发出了针对 MASP-2 的抗体，抗体可阻断 MASP-2 的酶活性，可作为潜在的 MASP-2 依赖性补体活化相关疾病的治疗药物。

关键词

补体，凝集素途径，MASP-2，抗体

参考

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