分子胶在蛋白质类药物研发中的应用

陈 紫盺¹, 刘 祚铭¹, 石 欣雨¹, 陈 小静¹, 王 倩¹, 王 子豪¹, 张 红艳²
1、沈阳药科大学 110016
2、通讯作者沈阳药科大学 110016

摘要

目的：蛋白质类药物是目前医药领域一种特别重要的药物，蛋白质之间的相互作用是一种特别重要的机制。靶向嵌合蛋白水解技术可以诱导靶向蛋白水解，但是很多的 PROTAC 抑制剂不是通过靶向蛋白的降解而发挥作用的。在最近几年的研究中，人们发现了分子胶作用机制。该技术目前属于前沿技术，没有进行大规模的应用，本文为大家综述了分子胶在蛋白质类药物研发中的应用，向大家阐述这一最新生命科学技术。

关键词

分子胶，靶向嵌合蛋白水解技术，蛋白质药物的研发

参考

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