环状RNA在甲状腺癌中的研究进展

姜 泰先¹, 刘 阁玲²
1、华北理工大学
2、唐山工人医院

摘要

甲状腺癌(thyroidcancer,TC)已成为最常见内分泌肿瘤,是近年来发病率最快的肿瘤,TC的存活率高于大多数其他类型的癌症,但它取决于许多因素,包括TC的具体类型和疾病的分期｡环状RNA(circRNA)是一类新型的长链非编码RNA,具有闭环结构,在控制TC发生的复杂基因调控网络中发挥着重要作用｡circRNA最重要的功能是特异性结合microRNAs的能力｡circRNA可以通过调节细胞周期以及影响细胞代谢等不同的途径调节TC侵袭和进展｡根据circRNA的特征,它们被确定为诊断肿瘤的潜在生物标志物｡本文就circRNA的功能､意义及其在TC发病中的潜在临床意义进行综述｡

关键词

环状RNA､甲状腺癌､ceRNAs调控网络

参考

[1]SALVATOREV,SILVIAF,FREDDIEB,etal.WorldwideThyroid-CancerEpidemic?TheIncreasingImpactofOverdiagnosis.TheNewEnglandjournalofmedicine[J].2016,375(7).[2]文静,殷成宇,廖国伟,etal.应用GM(1,1)灰色模型预测全国甲状腺癌发病趋势现代肿瘤医学[J].2022,30(05):899-902.[3]SIKAH,GILBERTWH.SouthKorea'sThyroid-Cancer"Epidemic"--TurningtheTide.TheNewEnglandjournalofmedicine[J].2015,373(24).[4]中华医学会放射学分会头颈学组.甲状腺结节影像检查流程专家共识中华放射学杂志[J].2016,50(12):911-5.[5]陈立波,丁勇,关海霞,etal.中国临床肿瘤学会(CSCO)持续/复发及转移性分化型甲状腺癌诊疗指南-2019肿瘤预防与治疗[J].2019,32(12):1051-80.[6]HUIHUIW,XIAOGUANGY,HAIJUNZ,etal.CircRNAcirc_0067934OverexpressionCorrelateswithPoorPrognosisandPromotesThyroidCarcinomaProgression[J].Medicalsciencemonitor:internationalmedicaljournalofexperimentalandclinicalresearch,2019,25.[7]LSH,GK,DR,etal.Viroidsaresingle-strandedcovalentlyclosedcircularRNAmoleculesexistingashighlybase-pairedrod-likestructures[J].ProceedingsoftheNationalAcademyofSciencesoftheUnitedStatesofAmerica,1976,73(11).[8]THM,MC-P.ElectronmicroscopicevidenceforthecircularformofRNAinthecytoplasmofeukaryoticcells[J].Nature,1979,280(5720).[9]WILUSZJE,SHARPPA.ACircuitousRoutetoNoncodingRNA[J].Science,2013,340(6131).[10]GMP,PETARG,SEBASTIANM,etal.AmapofhumancircularRNAsinclinicallyrelevanttissues[J].Journalofmolecularmedicine(Berlin,Germany),2017,95(11).[11]WUG,ZHOUW,LINX,etal.circRASSF2ActsasceRNAandPromotesPapillaryThyroidCarcinomaProgressionthroughmiR-1178/TLR4SignalingPathway[J].MolecularTherapy-NucleicAcids,2020,19(C).[12]WEIC,JUNX.CircularRNADOCK1downregulatesmicroRNA-124toinducethegrowthofhumanthyroidcancercelllines[J].BioFactors(Oxford,England),2020,46(4).[13]XIAOYANJ,ZHENGYIW,WENYANGP,etal.Upregulatedhsa_circ_0004458ContributestoProgressionofPapillaryThyroidCarcinomabyInhibitionofmiR-885-5pandActivationofRAC1[J].Medicalsciencemonitor:internationalmedicaljournalofexperimentalandclinicalresearch,2018,24.[14]JIANGYM,LIUW,JIANGL,etal.CircLDLRPromotesPapillaryThyroidCarcinomaTumorigenicitybyRegulatingmiR-637/LMO4Axis[J].Diseasemarkers,2021,2021:3977189.[15]HONGR,ZHENDIS,CHENC,etal.circCCDC66promotesthyroidcancercellproliferation,migratoryandinvasiveabilitiesandglycolysisthroughthemiR-211-5p/PDK4axis[J].OncologyLetters,2021,21(5).[16]JIAYUZ.CircRNA-ENO1promotedglycolysisandtumorprogressioninlungadenocarcinomathroughupregulatingitshostgeneENO1[J].Celldeath&disease,2019,10(12):885.[17]JIANINGL.Circ-SERPINE2promotesthedevelopmentofgastriccarcinomabyspongingmiR-375andmodulatingYWHAZ[J].Cellproliferation,2019,52(4):e12648.[18]ZHANGP,ZUOZ,SHANGW,etal.IdentificationofdifferentiallyexpressedcircularRNAsinhumancolorectalcancer[J].Tumourbiology:thejournaloftheInternationalSocietyforOncodevelopmentalBiologyandMedicine,2017,39(3):1010428317694546.[19]HAIYANGX.NFIXCircularRNAPromotesGliomaProgressionbyRegulatingmiR-34a-5pviaNotchSignalingPathway[J].Frontiersinmolecularneuroscience,2018,11:225.[20]XIABINL,JUNC,JIAJIEX,etal.Decreasedexpressionofhsa_circ_0137287predictsaggressiveclinicopathologiccharacteristicsinpapillarythyroidcarcinoma[J].Journalofclinicallaboratoryanalysis,2018,32(8).