急性缺血性卒中患者静脉溶栓后出血转化的研究现状

王 玉青¹, 李 佳宁¹, 周 彦君¹, 李 永秋², 马 佳丽³, 李 姗³
1、华北理工大学研究生院,唐山市工人医院
2、唐山市工人医院
3、唐山市工人医院,河北医科大学研究生院

摘要

在中国，急性缺血性脑卒中（Acute ischemic stroke,AIS）是导致患者致残和致死的首位原因[1]，目前指南推荐重组组织型纤溶酶原激活剂rt-PA是AIS患者在发病后4.5h内血管再通的最有效的治疗手段之一[2]，可以有效改善患者的临床神经功能缺损症状，降低死亡和严重致残的发生率。但静脉溶栓后导致的出血转化，尤其是症状性出血转化sICH，可使患者临床症状加重，造成患者脑组织不可逆损害、不良远期预后及神经功能结局。本文就溶栓后出血转化的类型、发病机制、危险因素及预测模型作一综述，为急性脑梗死患者的临床治疗做出指导。

关键词

急性缺血性卒中；阿替普酶；静脉溶栓；出血转化；预测模型

参考

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