中医药治疗癫痫伴认知障碍的研究进展 Research Progress of Traditional Chinese Medicine in Treating Epilepsy with Cognitive Impairment

何 聪¹, 唐 治强¹, 刘 征¹, Cong He², Zhiqiang Tang², Zheng Liu²
1、黑龙江中医药大学
2、Heilongjiang University of Traditional Chinese Medicine

摘要

大脑神经元异常放电是诱发癫痫的重要因素，认知功能障碍是严重影响癫痫患者生活质量最常见的并发症，以注意力不集中、记忆力下降等为主要临床表现。在中国知网、PubMed数据库查阅相关文献，从临床研究、动物研究两方面对近10年癫痫伴认知障碍的中医疗法进行系统总结，来寻找更有价值的治疗方法。 Abnormal discharge of brain neurons is an important factor to induce epilepsy. Cognitive dysfunction is the most common complication that seriously affects the quality of life of epileptic patients.In order to find a more valuable treatment, we systematically summarized the traditional Chinese medicine treatment of epilepsy with cognitive impairment in recent 10 years from clinical research and animal research by consulting relevant literature in China HowNet and PubMed database.

关键词

癫痫；认知障碍；中医；针刺；中药 Epilepsy; cognitive impairment; traditional chinese medicine; acupuncture; traditional chinese medicine

参考

[1] 涂雪松.癫痫的流行病学研究[J].脑与神经疾病杂志,2017,25(8):522-529. [2] Hauser, W. A., & Beghi, E. (2008). First seizure definitions and worldwide incidence and mortality.Epilepsia,49 Suppl 1, 8-12. [3] Loughman A, Bowden SC, D'Souza W. Cognitive functioning in idiopathic generalised epilepsies: a systematic review and meta-analysis.Neurosci Biobehav Rev. 2014;43:20-34 [4] Menlove, L., & Reilly, C. (2015). Memory in children with epilepsy: a systematic review.Seizure,25, 126-135. [5] 李进安,朱百科,王净净.癫痫认知障碍的中医病因病机探析[J].中医药导报,2007(3):12-14+49. [6] 朱遂强,罗利俊,陈辉,等.癫痫患者认知障碍与生存质量的相关研究[J].中华物理医学与康复杂志,2004(5):28-30. [7] Nicolai, J., Ebus, S., Biemans, D. P., Arends, J., Hendriksen, J., Vles, J. S., & Aldenkamp, A. P.(2012).The cognitive effects of interictal epileptiform EEG discharges and short nonconvulsive epileptic seizures.Epilepsia,53(6),1051-1059. [8] 遆悦,郑维红.癫痫与认知功能障碍研究进展[J].中国全科医学,2017,20(15):1818-1822. [9] Freitas, R. M., Vasconcelos, S. M., Souza, F. C., Viana, G. S., & Fonteles, M. M. (2005). Oxidative stress in the hippocampus after pilocarpine-induced status epilepticus in Wistar rats.The FEBS journal,272(6),1307-1312. [10] 叶雪雪,张丽芳.癫痫引起认知障碍机制研究进展[J].长治医学院学报,2019,33(4):317-320. [11] 麦华永,于征淼.从痰论治痫病文献研究[J].广州中医药大学学报,2020,37(2):376-382. [12] 周莲芝.涤痰汤加味治疗全面强直阵挛发作癫痫伴发认知障碍痰浊阻窍证临床观察[D].湖北中医药大学,2019. [13] 张林,钟艳,赵静,全淑林,刘叶辉,石学慧,李振光,刘春华,王净净.王净净从虚、痰、瘀、毒论治难治性癫痫经验[J].中国中医药信息杂 志,2018,25(08):108-110. [14] 杨雁,裴林,张少丹,等.调肝解毒方改善癫痫儿童认知功能 132 例临床观察[J].中医临床研究,2012,4(2):14-15. [15] 杨雁,王红艳,国献素.从肾论治癫痫认知障碍的中医理论探讨[J].中外医疗,2012,31(14):128. [16] 曹丽平,高敏.基于固本培元论治小儿癫痫认知障碍[J].中医杂志,2019,60(18):1555-1559. [17] 戎萍,张喜莲,马融,等."从肾论治"小儿癫痫的临床研究[J].天津中医药大学学报,2012,31(3):140-143. [18] 高珍,吉学群.吉学群运用针刺从督脉论治癫痫经验[J].湖南中医杂志,2018,34(11):38-40. [19] 黄树栋,陈方敏,简辽欣,等.天麻素胶囊联合针灸对成人癫痫患者认知功能及生活质量的影响[J].中国医药科学,2020,10(17):105-107+114. [20] 莫微,林志宏.中药远志改善记忆障碍研究进展[J].世界科学技术(中医药现代化),2012,14(4):1913-1916.