研究达格列净加二甲双胍缓释片与格列奇特加二甲双胍缓释片治疗二型糖尿病临床分析 Clinical analysis of dagliflozin plus metformin and gliclazide plus metformin in the treatment of type 2 diabetes

刘 自玖¹, Zijiu Liu²
1、金川县中藏医院
2、Jinchuan Zhongzang Hospital

摘要

目的：探讨在2型糖尿病（T2DM）中应用二甲双胍基础上，分别联合达格列净、格列齐特的效果。方法：2019年5月-2021年5月，选取我院收治的T2DM患者80例，随机分为两组，均给予二甲双胍治疗，研究组＋达格列净，对照组＋格列齐特，对比血糖指标、临床疗效及不良反应。结果：治疗后两组空腹血糖（FPG）、餐后2h血糖（2hPG）水平、血糖达标率、总有效率、不良反应发生率对比有差异（p＜0.05）。结论：在T2DM患者中采用二甲双胍＋达格列净治疗对血糖的控制情况较好，血糖达标率高，且对心肾保护作用良好。 Objective: To investigate the effect of metformin combined with dagliflozin and gliclazide in type 2 diabetes mellitus (T2DM).Methods: From May 2019 to May 2021,80 patients with T2DM who were treated in our hospital were randomly divided into two groups. The study group was treated with metformin and the control group was treated with gliclazide.Results: There were significant differences in fasting plasma glucose (FPG),2h postprandial plasma glucose (2hPG), blood glucose compliance rate, total effective rate and adverse reaction rate between the two groups (p <0.05).Conclusion: Metformin+dagliflozin treatment in patients with T2DM has a good control of blood glucose, high blood glucose rate, and good protective effect on heart and kidney.

关键词

2型糖尿病；达格列净；格列齐特 Type 2 diabetes; dagliflozin; gliclazide

参考

[1] Yun-Ying Hou,Omorogieva Ojo,Li-Li Wang,et al.A Randomized Controlled Trial to Compare the Effect of Peanuts and Almonds on the Cardio-Metabolic and Inflammatory Parameters in Patients with Type 2 Diabetes Mellitus[J]. Nutrients.2018 Oct 23;10(11):1565. [2] 刘林,王薇,张婷婷,等.达格列净对 2 型糖尿病患者血,尿电解质及尿酸影响的病例观察[J].中国糖尿病杂志,2020,28(5):345-349. [3] 中华医学会糖尿病学分会.中国 2 型糖尿病防治指南(2017 年版)[J].中国实用内科杂志,2018,38(4):292-344. [4] Carole Piera-Mardemootoo,Philippe Lambert,Jean-Luc Faillie.Efficacy of metformin on glycemic control and weight in drug-naive type 2 diabetes mellitus patients: A systematic review and meta-analysis of placebo-controlled randomized trials[J]. Therapie.Nov-Dec 2021;76(6):647-656. [5] 刘凌雪.格列齐特对 2 型糖尿病患者临床治疗效果及生命质量的影响[J].医疗装备,2020,33(2):129-130. [6] 杨艳玲,汤云昭,倪长霖.达格列净联合二甲双胍与吡格列酮治疗 2 型糖尿病的临床观察[J].中国慢性病预防与控制,2019,27(8):611-614. [7] 甄霞,顾红燕,文祯,等.达格列净联合胰岛素治疗特定 2 型糖尿病住院患者的疗效与安全性分析[J].中国医院药学杂志,2019,39(4):385-389.